ASBMRの発表内容の抄録
A New Method of Measurement of Mandibular Bone Mineral Density and Correlations with Dental Clinical Findings. Author Block Y. Takaishi*1, T. Ikeo*2, H. Morii3, M. Takeda*4, K. Hide*5, T. Arai*4, K. Nonaka*6. 1Takaishi Dental Clinic, Himeji, Japan, 2Osaka Dental University, Osaka, Japan, 3Emeritus Professor, Osaka City University, Osaka, Japan, 4Furuno Electric Co.,Ltd., Nishinomiya, Japan, 5Furuno Electric Co.,Ltd, Nishinomiya, Japan, 6Elk Corporation, Tokyo, Japan. While alveolar bones have been supposed to be affected by the process of osteoporosis as a systemic disease, it is important to evaluate how is bone mineral density (BMD) of alveolar bones from standpoint of both dental and medical practice. Forty post-menopausal Japanese women with the mean age 59.4±5.6(SD) years were studied with the written consent for the study. Twenty women were in their fifties and the rest in their sixties. Many methods of measurement of BMD of alveolar bones have been proposed, but the root area of mandibular first premolar was selected for measurement of BMD in the present study. A definite area of the root of the mandibular first premolar was divided into squares for measurement of brightness of each square from the soft ware developed by us. The distribution curve of brightness of each square was obtained and the mean value was calculated for each patient. Lumbar spine BMD was measured by Hologic QDR 4500W and the speed of sound (SOS) of calcaneous by quantitative ultrasound (QUS) by CM-100 (Furuno Electric, Co, Nihinomiya). Age-related significant decrease of alveolar BMD was demonstrated. There were significant correlations between alveolar BMD and lumbar spine BMD and between alveolar BMD and calcaneous SOS. Dentist made dental clinical observations including the depth of pockets, mobility of teeth and alveolar bone resorption by the method of Schei. Biochemical parameters of bone turnover were measured including bone alkaline phosphatase (BAP) and urinary deoxypyridinoline (DPD). Lumbar spine BMD showed significant negative correlation with BAP but the coefficient correlations between alveolar BMD and calcaneous BMD and BAP did not reach significant level. Multivariate analysis of factors in relation to dental clinical findings (attachment level) showed significant contributions of age, BAP, urinary DPD, urinary calcium/creatinine and calcaneous SOS. In conclusion, analysis of bone density at the root of mandibular first premolar could be an indicator of bone loss in patients with osteoporosis and periodontal diseases. There was an age-related bone loss from this method of measurement of alveolar BMD. However, it seemed that many factors may contribute to the bone loss in alveolar bones in addition to risk factors which may contribute to the pathogenesis of systemic osteoporosis . Author Disclosure Block: Y. Takaishi, None.
A New Method of Measurement of Mandibular Bone Mineral Density and Correlations with Dental Clinical Findings. Author Block Y. Takaishi*1, T. Ikeo*2, H. Morii3, M. Takeda*4, K. Hide*5, T. Arai*4, K. Nonaka*6. 1Takaishi Dental Clinic, Himeji, Japan, 2Osaka Dental University, Osaka, Japan, 3Emeritus Professor, Osaka City University, Osaka, Japan, 4Furuno Electric Co.,Ltd., Nishinomiya, Japan, 5Furuno Electric Co.,Ltd, Nishinomiya, Japan, 6Elk Corporation, Tokyo, Japan. While alveolar bones have been supposed to be affected by the process of osteoporosis as a systemic disease, it is important to evaluate how is bone mineral density (BMD) of alveolar bones from standpoint of both dental and medical practice. Forty post-menopausal Japanese women with the mean age 59.4±5.6(SD) years were studied with the written consent for the study. Twenty women were in their fifties and the rest in their sixties. Many methods of measurement of BMD of alveolar bones have been proposed, but the root area of mandibular first premolar was selected for measurement of BMD in the present study. A definite area of the root of the mandibular first premolar was divided into squares for measurement of brightness of each square from the soft ware developed by us. The distribution curve of brightness of each square was obtained and the mean value was calculated for each patient. Lumbar spine BMD was measured by Hologic QDR 4500W and the speed of sound (SOS) of calcaneous by quantitative ultrasound (QUS) by CM-100 (Furuno Electric, Co, Nihinomiya). Age-related significant decrease of alveolar BMD was demonstrated. There were significant correlations between alveolar BMD and lumbar spine BMD and between alveolar BMD and calcaneous SOS. Dentist made dental clinical observations including the depth of pockets, mobility of teeth and alveolar bone resorption by the method of Schei. Biochemical parameters of bone turnover were measured including bone alkaline phosphatase (BAP) and urinary deoxypyridinoline (DPD). Lumbar spine BMD showed significant negative correlation with BAP but the coefficient correlations between alveolar BMD and calcaneous BMD and BAP did not reach significant level. Multivariate analysis of factors in relation to dental clinical findings (attachment level) showed significant contributions of age, BAP, urinary DPD, urinary calcium/creatinine and calcaneous SOS. In conclusion, analysis of bone density at the root of mandibular first premolar could be an indicator of bone loss in patients with osteoporosis and periodontal diseases. There was an age-related bone loss from this method of measurement of alveolar BMD. However, it seemed that many factors may contribute to the bone loss in alveolar bones in addition to risk factors which may contribute to the pathogenesis of systemic osteoporosis . Author Disclosure Block: Y. Takaishi, None.
